Making risky decisions to take drug: Effects of cocaine abstinence in cocaine users.
Identifieur interne : 000853 ( Main/Exploration ); précédent : 000852; suivant : 000854Making risky decisions to take drug: Effects of cocaine abstinence in cocaine users.
Auteurs : Richard W. Foltin [États-Unis] ; Suzette M. Evans [États-Unis] ; Margaret Haney [États-Unis] ; Kenneth Carpenter [États-Unis] ; Gillinder Bedi [Australie]Source :
- Pharmacology, biochemistry, and behavior [ 1873-5177 ] ; 2019.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Bonbons (MeSH), Cocaïne (MeSH), Ennui (MeSH), Fumer de la cocaïne (MeSH), Humains (MeSH), Motivation (MeSH), Mâle (MeSH), Patients hospitalisés (MeSH), Population d'origine africaine (MeSH), Prise de décision (physiologie), Prise de risque (MeSH), Syndrome de sevrage (psychologie), Syndrome de sevrage (urine), Troubles liés à la cocaïne (psychologie), Troubles liés à la cocaïne (urine).
- MESH :
- physiologie : Prise de décision.
- psychologie : Syndrome de sevrage, Troubles liés à la cocaïne.
- Adulte, Adulte d'âge moyen, Bonbons, Cocaïne, Ennui, Fumer de la cocaïne, Humains, Motivation, Mâle, Patients hospitalisés, Population d'origine africaine, Prise de risque, Syndrome de sevrage, Troubles liés à la cocaïne.
English descriptors
- KwdEn :
- Adult (MeSH), African Continental Ancestry Group (MeSH), Boredom (MeSH), Candy (MeSH), Cocaine (MeSH), Cocaine Smoking (MeSH), Cocaine-Related Disorders (psychology), Cocaine-Related Disorders (urine), Decision Making (physiology), Humans (MeSH), Inpatients (MeSH), Male (MeSH), Middle Aged (MeSH), Motivation (MeSH), Risk-Taking (MeSH), Substance Withdrawal Syndrome (psychology), Substance Withdrawal Syndrome (urine).
- MESH :
- chemical : Cocaine.
- physiology : Decision Making.
- psychology : Cocaine-Related Disorders, Substance Withdrawal Syndrome.
- urine : Cocaine-Related Disorders, Substance Withdrawal Syndrome.
- Adult, African Continental Ancestry Group, Boredom, Candy, Cocaine Smoking, Humans, Inpatients, Male, Middle Aged, Motivation, Risk-Taking.
Abstract
Risky decision-making is characteristic of drug users, but little is known about the effects of circumstances, such as abstinence, on risky choice behavior in human drug users. We hypothesized that cocaine users would make more risky choices for cocaine (defined as taking a chance to receive a large number of cocaine doses as opposed to choosing to receive a fixed amount of cocaine) after 3 or 7 days of cocaine abstinence, compared to 1 day of cocaine abstinence. Six male nontreatment-seeking current cocaine smokers were enrolled in a 21-day inpatient within-subject study. Participants repeatedly smoked six 25 mg doses of cocaine during a training session and were instructed that they would be making decisions about smoking this dose throughout the study. After 1, 3 and 7 days of cocaine abstinence, participants completed a computerized task in which they repeatedly decided between receiving a guaranteed number of cocaine doses (between 1 and 5; fixed option) or receiving a chance (0.13 to 0.75) to smoke a larger number of cocaine doses (probabilistic option). After completing the computerized task, one of the participants' choices was randomly implemented and they smoked either the fixed number of cocaine doses or had the specified chance to smoke the greater number of doses. Contrary to our hypothesis, 5 of the 6 participants made fewer risky choices after 3 and 7 days of cocaine abstinence compared to one day of abstinence suggesting greater risk-aversion. Thus, even during cocaine abstinence cocaine users make rational decisions related to their drug use.
DOI: 10.1016/j.pbb.2018.12.008
PubMed: 30584902
PubMed Central: PMC7059600
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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(MeSH)</term><term>Motivation (MeSH)</term><term>Mâle (MeSH)</term><term>Patients hospitalisés (MeSH)</term><term>Population d'origine africaine (MeSH)</term><term>Prise de décision (physiologie)</term><term>Prise de risque (MeSH)</term><term>Syndrome de sevrage (psychologie)</term><term>Syndrome de sevrage (urine)</term><term>Troubles liés à la cocaïne (psychologie)</term><term>Troubles liés à la cocaïne (urine)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Cocaine</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Prise de décision</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Decision Making</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Syndrome de sevrage</term><term>Troubles liés à la cocaïne</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Cocaine-Related Disorders</term><term>Substance Withdrawal 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decision-making is characteristic of drug users, but little is known about the effects of circumstances, such as abstinence, on risky choice behavior in human drug users. We hypothesized that cocaine users would make more risky choices for cocaine (defined as taking a chance to receive a large number of cocaine doses as opposed to choosing to receive a fixed amount of cocaine) after 3 or 7 days of cocaine abstinence, compared to 1 day of cocaine abstinence. Six male nontreatment-seeking current cocaine smokers were enrolled in a 21-day inpatient within-subject study. Participants repeatedly smoked six 25 mg doses of cocaine during a training session and were instructed that they would be making decisions about smoking this dose throughout the study. After 1, 3 and 7 days of cocaine abstinence, participants completed a computerized task in which they repeatedly decided between receiving a guaranteed number of cocaine doses (between 1 and 5; fixed option) or receiving a chance (0.13 to 0.75) to smoke a larger number of cocaine doses (probabilistic option). After completing the computerized task, one of the participants' choices was randomly implemented and they smoked either the fixed number of cocaine doses or had the specified chance to smoke the greater number of doses. Contrary to our hypothesis, 5 of the 6 participants made fewer risky choices after 3 and 7 days of cocaine abstinence compared to one day of abstinence suggesting greater risk-aversion. Thus, even during cocaine abstinence cocaine users make rational decisions related to their drug use.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30584902</PMID><DateCompleted><Year>2019</Year><Month>12</Month><Day>31</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5177</ISSN><JournalIssue CitedMedium="Internet"><Volume>177</Volume><PubDate><Year>2019</Year><Month>02</Month></PubDate></JournalIssue><Title>Pharmacology, biochemistry, and behavior</Title><ISOAbbreviation>Pharmacol Biochem Behav</ISOAbbreviation></Journal><ArticleTitle>Making risky decisions to take drug: Effects of cocaine abstinence in cocaine users.</ArticleTitle><Pagination><MedlinePgn>20-26</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0091-3057(18)30343-5</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.pbb.2018.12.008</ELocationID><Abstract><AbstractText>Risky decision-making is characteristic of drug users, but little is known about the effects of circumstances, such as abstinence, on risky choice behavior in human drug users. We hypothesized that cocaine users would make more risky choices for cocaine (defined as taking a chance to receive a large number of cocaine doses as opposed to choosing to receive a fixed amount of cocaine) after 3 or 7 days of cocaine abstinence, compared to 1 day of cocaine abstinence. Six male nontreatment-seeking current cocaine smokers were enrolled in a 21-day inpatient within-subject study. Participants repeatedly smoked six 25 mg doses of cocaine during a training session and were instructed that they would be making decisions about smoking this dose throughout the study. After 1, 3 and 7 days of cocaine abstinence, participants completed a computerized task in which they repeatedly decided between receiving a guaranteed number of cocaine doses (between 1 and 5; fixed option) or receiving a chance (0.13 to 0.75) to smoke a larger number of cocaine doses (probabilistic option). After completing the computerized task, one of the participants' choices was randomly implemented and they smoked either the fixed number of cocaine doses or had the specified chance to smoke the greater number of doses. Contrary to our hypothesis, 5 of the 6 participants made fewer risky choices after 3 and 7 days of cocaine abstinence compared to one day of abstinence suggesting greater risk-aversion. Thus, even during cocaine abstinence cocaine users make rational decisions related to their drug use.</AbstractText><CopyrightInformation>Copyright © 2019 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Foltin</LastName><ForeName>Richard W</ForeName><Initials>RW</Initials><AffiliationInfo><Affiliation>Division on Substance Use Disorders, New York State Psychiatric Institute, Department of Psychiatry, Columbia University Medical Center, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA. Electronic address: rwf2@cumc.columbia.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Evans</LastName><ForeName>Suzette M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Division on Substance Use Disorders, New York State Psychiatric Institute, Department of Psychiatry, Columbia University Medical Center, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haney</LastName><ForeName>Margaret</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division on Substance Use Disorders, New York State Psychiatric Institute, Department of Psychiatry, Columbia University Medical Center, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carpenter</LastName><ForeName>Kenneth</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Division on Substance Use Disorders, New York State Psychiatric Institute, Department of Psychiatry, Columbia University Medical Center, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bedi</LastName><ForeName>Gillinder</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Melbourne University, Orygen National Centre of Excellence in Youth Mental Health, 35 Poplar Road, Parkville, Victoria 3052, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>K05 DA031749</GrantID><Acronym>DA</Acronym><Agency>NIDA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 DA021319</GrantID><Acronym>DA</Acronym><Agency>NIDA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 RR024156</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>12</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Pharmacol Biochem Behav</MedlineTA><NlmUniqueID>0367050</NlmUniqueID><ISSNLinking>0091-3057</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>I5Y540LHVR</RegistryNumber><NameOfSubstance UI="D003042">Cocaine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044383" MajorTopicYN="N">African Continental Ancestry Group</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001887" MajorTopicYN="N">Boredom</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002182" MajorTopicYN="N">Candy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003042" MajorTopicYN="Y">Cocaine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000074101" MajorTopicYN="N">Cocaine Smoking</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019970" MajorTopicYN="N">Cocaine-Related Disorders</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003657" MajorTopicYN="N">Decision Making</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007297" MajorTopicYN="N">Inpatients</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009042" MajorTopicYN="N">Motivation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012309" MajorTopicYN="Y">Risk-Taking</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013375" MajorTopicYN="N">Substance Withdrawal Syndrome</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Abstinence</Keyword><Keyword MajorTopicYN="Y">Cocaine</Keyword><Keyword MajorTopicYN="Y">Decision making</Keyword><Keyword MajorTopicYN="Y">Expected value</Keyword><Keyword MajorTopicYN="Y">State dependent valuation</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate 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Foltin</name></region><name sortKey="Carpenter, Kenneth" sort="Carpenter, Kenneth" uniqKey="Carpenter K" first="Kenneth" last="Carpenter">Kenneth Carpenter</name><name sortKey="Evans, Suzette M" sort="Evans, Suzette M" uniqKey="Evans S" first="Suzette M" last="Evans">Suzette M. Evans</name><name sortKey="Haney, Margaret" sort="Haney, Margaret" uniqKey="Haney M" first="Margaret" last="Haney">Margaret Haney</name></country><country name="Australie"><noRegion><name sortKey="Bedi, Gillinder" sort="Bedi, Gillinder" uniqKey="Bedi G" first="Gillinder" last="Bedi">Gillinder Bedi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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